WASHINGTON — A team of interdisciplinary scientists at the Medical University of South Carolina and the Charleston VA Medical Center Research Service recently reviewed published literature for evidence of a relationship between antibiotic use in agricultural animals and drug-resistant foodborne Salmonella infections in humans, commonly known as salmonellosis. According to the 2013 CDC Antibiotic Resistance Threats Report, two of the eighteen pathogens that are of concern in the United States may have a direct link to agriculture — one of them being Salmonella.
Foodborne illness from both drug-sensitive and drug-resistant non-typhoidal Salmonella is estimated to sicken 1.2 million Americans annually (CDC, 2013). The study — conducted by veterinary and nutrition scientists and an infectious disease physician — reviewed 104 articles in the U.S., Canada, Denmark, Scotland and Ireland over the past five years and has been published in [volume 57, issue 3] ofCritical Reviews in Food Science and Nutrition. Animals included in the reviewed studies were chicken, turkeys, pigs, beef cattle, and dairy cows.
The overall prevalence of Salmonella and drug-resistance found in the systematic review aligns with recent National Antimicrobial Resistance Monitoring System (NARMS) reports. The 2013 NARMS report showed that 81% of the Salmonella from human infections carried no resistance to any antibiotic, while Salmonella resistance rates in animals vary by the antibiotic tested. The findings of this systematic review did lead the team to important concerns about Salmonella and demonstrated that more research in this area is needed. For example, six articles showed increased antibiotic resistance in organisms derived from animals, not retail meats, used in conventional farming, versus those from antibiotic-free operations. No studies were found that followed animal-associated antibiotic resistant isolates from farm to retail products.
Lead scientist Kristi Helke, D.V.M., Ph.D. remarked, “While there were some studies worth noting in our review, it is most apparent that there is a greater need for a more robust data collection system and heightened publication expectations in the U.S. for transparency in antibiotic usage in both animals and humans. There is still much more research to be done. The agriculture and health care industries must work hand-in-hand with the scientific community, government regulatory agencies and human health community in order to ensure safe, humane, and affordable food sources to the public.”
Richard A. Carnevale, V.M.D., Vice President for Regulatory, Scientific and International Affairs at the Animal Health Institute (AHI), who funded the study said, “On January 1, the agriculture community took an important step in promoting the effectiveness of antibiotics by being in full compliance with new FDA mandates—Guidance 209 and 213—which eliminates the use of medically important antibiotics for growth promotion purposes and requires approval by a licensed veterinarian for all remaining uses in feed through the veterinary feed directive. The proper public health focus—in both humans and animals—should be on using antibiotics only when necessary to fight disease. We support this research and more research like it to promote a positive impact on public health.”
Principal investigator on the study, Bernadette Marriott, Ph.D., stated, “Our research results underscore the need for both veterinarians and physicians to work together as we advance toward solutions to concerns about antibiotic resistance.”
ABOUT THE STUDY AUTHORS
MUSC authors of this study are: Kristi L. Helke, M.A. McCrackin, D.V.M., Ph.D., Ashley Galloway, M.S., R.D., Ann Z. Poole, M.Ed.,Cassandra Salgado, M.D., M.S., and Bernadette P. Marriott, Ph.D.. A similar systematic review of Campylobacter was also conducted and the findings were published in 2016.
The authors state that they are solely responsible for the contents of the study, its results and conclusions. The contents of this article and the contents of the authors’ study represent the views and findings of the authors and do not represent the views of the Department of Veterans Affairs, the United States Government, or MUSC.
In 2015, Medical University of South Carolina (MUSC) researchers received $247 million in total awards, were responsible for 69 new inventions and had 646 patent filings. There more than 424 members of the MUSC research faculty. Founded in 1824 in Charleston, MUSC is the oldest medical school in the South. Today, MUSC continues the tradition of excellence in education, research, and patient care. MUSC educates and trains more than 3,000 students and residents, and has nearly 13,000 employees, including approximately 1,500 faculty members. As the largest non-federal employer in Charleston, the university and its affiliates have collective annual budgets in excess of $2.2 billion. MUSC operates a 750-bed medical center, which includes a nationally recognized Children’s Hospital, the Ashley River Tower (cardiovascular, digestive disease, and surgical oncology), Hollings Cancer Center (a National Cancer Institute designated center) Level I Trauma Center, and Institute of Psychiatry. For more information on academic information or clinical services, visit musc.edu. For more information on hospital patient services, visit muschealth.org.
—Animal Health Institute
Medical University of South Carolina
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